The formation of skin barrier and defective barrier-associated skin diseases
نویسندگان
چکیده
منابع مشابه
Cytokines and the Skin Barrier
The skin is the largest organ of the human body and builds a barrier to protect us from the harmful environment and also from unregulated loss of water. Keratinocytes form the skin barrier by undergoing a highly complex differentiation process that involves changing their morphology and structural integrity, a process referred to as cornification. Alterations in the epidermal cornification proc...
متن کاملDefective channels lead to an impaired skin barrier.
Channels are integral membrane proteins that form a pore, allowing the passive movement of ions or molecules across a membrane (along a gradient), either between compartments within a cell, between intracellular and extracellular environments or between adjacent cells. The ability of cells to communicate with one another and with their environment is a crucial part of the normal physiology of a...
متن کاملSkin Barrier Protection
The largest organ of the human body is the skin with its ∼2 m 2 surface area that envelopes the whole organism defining its physical border and which most importantly provides a barrier against internal organ dehydration and external penetration of noxious substances. The critical importance of the skin barrier is appreciated when it is lost such as in skin burns or compromised such as in atopi...
متن کاملSkin barrier in rosacea*
Recent studies about the cutaneous barrier demonstrated consistent evidence that the stratum corneum is a metabolically active structure and also has adaptive functions, may play a regulatory role in the inflammatory response with activation of keratinocytes, angiogenesis and fibroplasia, whose intensity depends primarily on the intensity the stimulus. There are few studies investigating the ab...
متن کاملThe skin: an indispensable barrier.
The skin forms an effective barrier between the organism and the environment preventing invasion of pathogens and fending off chemical and physical assaults, as well as the unregulated loss of water and solutes. In this review we provide an overview of several components of the physical barrier, explaining how barrier function is regulated and altered in dermatoses. The physical barrier is main...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2017
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.40.416